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| Calcium-sensing receptor ： ウィキペディア英語版 |
Calcium-sensing receptor
The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. In the parathyroid gland, the calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone (PTH).
==Signal transduction==
The release of PTH is inhibited in response to elevations in plasma calcium concentrations and activation of the calcium receptor. Increased calcium binding on the extracellular side gives a conformational change in the receptor, which, on the intracellular side, initiates the phospholipase C pathway,〔(InterPro: IPR000068 GPCR, family 3, extracellular calcium-sensing receptor-related ) Retrieved on June 2, 2009〕 presumably through a Gqα type of G protein, which ultimately increases intracellular concentration of calcium, which inhibits vesicle fusion and exocytosis of parathyroid hormone. It also inhibits (not stimulates, as some sources state) the cAMP dependent pathway.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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